Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.ĭisruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair.Ĭonditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.įan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction. View source on a small sample size noted that 5 out of 102 cases had a genetic history of nocturnal lagophthalmos. It affects 1.4 percent of the adult population. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Nocturnal lagophthalmos is a condition in which the affected people are unable to close their eyes properly during sleep. Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. About 5 of adults sleep with their eyes at least somewhat open. If the problem only occurs when you sleep, its called nocturnal lagophthalmos. But this condition, known as nocturnal lagophthalmos, isnt uncommon. Lagophthalmos is a condition that prevents the eyes from closing completely. People who sleep with their eyes partially or completely open usually have no idea their eyelids arent closing during the night. TitleĪ Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. A condition known as nocturnal lagophthalmos. Nocturnal lagophthalmos: an overview and classification. 4 Keep in mind that it is as important to examine the closed eye as it is the open eye in order to clue in to this subtle and easily overlooked pathology. There are 11 publications which use IMPC produced mice or data. Estimates suggest four to 20 percent of the population have lagophthalmos.
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